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Bench and Pilot-Scale Steam-In-Place Systems

SIP-with-ezControl-webApplikon’s concept of modularity (using standard modules to customize the functions of the bioreactor) is extended to the stainless steel pilot plant bioreactors as well. For scale up purposes the range of the Bio Bench and Pilot Systems, designed and built to the latest standards on hygienic processing and cGMP and GAMP validation requirements, comple¬ments the laboratory scale bioreactor systems. Scale-up from laboratory scale to
pilot plant and small scale production is simplified by the consistent bioreactor design and the scalable control solutions.

Features and Applications

SIP-with-ezControl-webAll systems are designed to be cleaned-in-place. Applikon offers CIP systems ranging from fully manual control to fully automated. Standardized bioreactor systems are available up to 140 liter total volume and custom build units can be supplied up to 2000 liter total volume.

Features

  • Easy to clean mirror polished external finish
  • Electropolished finish of all parts in contact with the culture (Ra = 0.4 μm) to allow efficient clean-in-place
  • Modular design allows easy adaptation to changing process demands
  • Magnetically coupled agitator for peace of mind
  • cGMP compliant design simplifies validation
  • Compact design reduces floor space needed
  • Open frame construction gives easy access for maintenance and operation

Applications

  • Scale-up studies
  • Medium optimization
  • Process optimization
  • Small scale production
  • Microbial and Cell culture
  • Batch, Fed-Batch, Perfusion and Continuous cultivation

Specifications

sip-side-webCustom specifications are also available. Contact your Applikon representative to learn more.

  Total Volume (L)  Working Volume (L)  Minimum Working Volume (L) 
7L BioBench   7 5
15L BioBench  15  10 
20L BioBench  20  15 
30L BioBench 30 22.5 7
30L BioPilot Cell 30 20 7.5
60L BioPilot Cell 60 40 10
130L BioPilot Cell 130 100 28
20L BioPilot Microbial 20 15 4
40L BioPilot Microbial 40 30 7.5
70L BioPilot Microbial 70 50 10
140L BioPilot Microbial 140 100 20
Custom build bioreactor systems are available up to 2,000L total volume
Drive System

Direct drive, magnetically coupled, optional mechanical seal, bottom or top mounted agitator for microbial cultures and top mounted for cell cultere systems

Impellers Rushton and marine with outside diameters 0.33 – 0.5 vessel diameter
Gas Sparger Porous sparger or Ring-type sparger
Gas Ovelray Optional gas overlay line
Exhaust Gas Water cooled exhaust gas condenser with internal spiral and/or jacketed
Sampling Optional resterilizable sample system in DN25 port in lower side wall
Draining Resterilizable bottom mounted bellows drain
Additions Sterilizable additions (push valves) and resterilizable addition ports
pH Measurement: 12 mm classic pH sensor in DN25 port in lower side wall
  Control: via acid pump or CO2 gas (rotameter or MFC) in combination with alkali pump
Dissolved Oxygen Measurement: 12 mm polarographic DO2 sensor in DN25 port in lower side wall
  Control: via a combination of N2, Air, O2 (Rotameter or MFC) and agitation or nutrient addition pump
Temperature Measurement: Pt-100 sensor in in DN25 port in lower side wall
  Cultivation control: cooling and heating jacket via bioreactor wall
Foam Measurement: Height adjustable conductivity based foam sensor
  Control: Anti foam addition pump
Level Measurement: Height adjustable conductivity based level sensor or loadcells in bioreactor frame
  Control: pump for liquid addition or removal

Learn More

Controller Systems for Sterilize-in-Place Bioreactors

Learn more about our ezControl process controller.

Learn more about our iControl industrial control platform

Request More Information

Contact your Applikon representative to learn more about our SIP systems.

Request more information on Steam-In-Place systems

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